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The trade-off is tolerability

Because there is not enough high-quality human evidence to support routine clinical use and they are not currently approved for use in Humans by Health Canada or the FDA

Additionally, histological assessment involved Tyrosine Hydroxylase (TH) staining in the substantia nigra to evaluate the integrity and potential restoration of dopaminergic neurons, with evaluations performed at 1 month and 3 months post-lesion

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This condition can lead to vision loss and blindness

In human narcolepsy patients there is a significant reduction in the amount of detectable orexin A and orexin B as well as an 80%100% reduction in the number of neurons that contain detectable prepro-orexin mRNA