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It should be noted that processes dependent on the adenosylcobalamin cofactor are more numerous and more developed [16,17,18,19], and they also support the transfer of hydrogen between substrates [20,21,22,23,24] after the breaking of the Co- C bond [4, 25,26,27,28,29]
Interplay analysis: cysteine metabolism, autophagy and AA Cysteine plays a pivotal role in a myriad of cellular functions, spanning from protein synthesis and detoxification to metabolism (Tikhomirova et al
Next, Cys63 nucleophilically attacks the sulfide of Cys58, releasing a GS-anion, which, in turn, picks up a solvent proton and is released from the enzyme, thereby creating the second GSH
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10.1016/j.celrep.2020.107538 Cell Rep
Next, the AsA is displaced by GSH binding for the second reaction
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