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Special considerations : The FDA prescribing information for tirzepatide notes that it may decrease exposure to oral contraceptives, particularly during dose initiation and escalation

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Weight regain is common when stopping semaglutide, with clinical studies showing patients often regain a significant portion of lost weight within one year of discontinuation

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2021;385(6)(suppl):503-515

Some individuals also report an increase in their resting heart rate, which must be monitored closely in patients with cardiac disease