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Typically worst at weeks 6 to 14

Liver fat content decreased significantly, with corresponding improvements in liver enzyme levels

Early Clinical Results: In two small clinical studies, GLP-1 agonists reduced alcohol consumption and craving in patients with alcohol use disorder and reduced opioid craving by 40% among opioid use disorder patients 5 Bajaj, S

Weight loss may plateau, blood glucose targets remain out of reach, or side effects limit long-term use

Most providers consider any variance under 5% to be clinically insignificant