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[2] [1] For patients with neurological symptoms , hydroxocobalamin 1 mg is given intramuscularly on alternate days until no further improvement occurs, followed by maintenance injections every two months for life
Disadvantages Smaller capacity for medicine
This timeline matches B12 pharmacokinetics: intramuscular methylcobalamin reaches peak serum concentration at 8-12 hours, but tissue saturation (particularly in the liver and nervous system) occurs over 48-72 hours as the vitamin is transported into cells and converted to active coenzyme forms (Andrs et al., 2018)
Yoshino J, et al
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