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6 The phase 2 monotherapy dose-finding trial by Lau and colleagues established that once-weekly cagrilintide up to 4.5 mg produced dose-dependent weight loss about 10.8% at the top dose over 26 weeks with a gastrointestinal side-effect profile (nausea and related symptoms) that is the clinical fingerprint of a gut-slowing, satiating mechanism

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This review is part of a larger project, and we present this companion review, which provides a detailed examination of the literature beyond polyphenols and/or phytoestrogens for estrogen-deficient skin