reported that carrying of the GSTM1 null genotype, the GSTP1 A/B or B/B genotype, and the GSTA1 A/B or B/B genotype is associated with higher risk for MASLD development, as these genotypes show lower substrate affinity or lower hepatic expression compared to wild-type genotypes (Oniki et al
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Gee, MD, FACOG
Similarly, in breast cancer, LOH at this locus occurred in approximately 36% of breast cancer tissues, and GPx1 with a leucine-containing allele exhibited lower GPx1 activities in response to stimulation than GPx1 a proline-containing allele [88]