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BioMed Research International, 2012, 153626

The term natural does not automatically mean safer. Herbal supplements are not regulated as strictly as prescription drugs and can have powerful biological effects or interact dangerously with other medications

The abdomen tends to produce milder reactions than the thigh for most users, likely because abdominal subcutaneous fat provides a more consistent depot environment with fewer blood vessels

Take it on an empty stomach

Serious but rare side effects include pancreatitis (0.3%), gallbladder events (1.4%), and acute kidney injury associated with dehydration (0.7%)