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Glucagon-like peptide-1 receptor agonists (GLP-1s) were originally developed for people with diabetes, but have skyrocketed in popularity for their weight loss effects
Lancet Diabetes Endocrinol 2024;12:162-173
Retatrutide works on the GLP1 and GIP receptors, but also targets glucagon as well
Do not wait for routine labs Severe abdominal pain, persistent vomiting, signs of dehydration, fainting, allergic symptoms, or severe low-glucose symptoms need medical review
They are very similar
Significant weight loss typically becomes noticeable within the first one to two months, with continued progress over time
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