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On the other hand, ERK showed reduced phosphorylation in GNE mutant cells even after IGF-1 treatment suggesting downregulation of the ERK pathway

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Typical dosing range: Compounding-clinic protocols (for example, as documented by TrimRx) describe a loading phase of 2-5 mg twice weekly for 4-6 weeks, followed by a maintenance phase of 2-2.5 mg once weekly

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Second, some associations, including the association with CAD, did not reach Bonferroni-corrected significance, so we cannot exclude the possibility of a chance finding