And I was like, this is so interesting
There are so many questions around access and maintaining treatment if that is truly, like, the most effective way to deliver these drugs, and we still do need those long-term studies
The presence of multiple intracellular signaling systems suggests potential plasticity in GLP-1 action and supports the hypothesis that selective engagement of GLP-1R could preferentially recruit beneficial signaling pathways
Hangzhou Jiuyuan Gene Engineering (a subsidiary of Huadong Medicine) filed for marketing approval with the National Medical Products Administration (NMPA) in April 2024
Those drugs have different molecular structures than orforglipron, Wharton says, which could explain why orforglipron didnt cause the same trouble
Research shows that GLP-1 agonists stimulate fluid secretion in the colon and increase intestinal permeability in some patients