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The Framingham Offspring study found that 39% of the general population may be in the low normal + deficient B12 blood level range

These pathways include those related to oxidative stress and inflammation, lipid metabolism, GLUT4 expression and translocation, and the SIRT1/AMPK signaling axis (251)

doi: 10.3389/fimmu.2023.1235514 73 HouJXuPZhongYZhouZZhangW

doi: 10.1016/j.amjmed.2014.10.014 218

Consistently, PQQ was able to increase GSH expression and Gpx4 activity in cardiomyocytes in vivo and in vitro, in addition to augmenting the FSP1-CoQ10 axis to protect against ferroptosis-associated damage

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