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A crucial step will be to perform a rigous retrospective validation after harmonized preprocessing (including consistent expression units and rigorous batch correction) to ensure the technical reliability of the analysis

10.1371/journal.pone.0211942 201 PanX.ChenZ.FeiG.PanS.BaoW.RenS.et al (2016)

This personalised approach to titration is an important safety feature and underscores why retatrutide must only be used under close medical supervision within an approved research framework

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In fact, one of the patients in the phase 2 study for BED died because of toxicology findings consistent with a methamphetamine overdose. So clearly this concern deserves close scrutiny