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Phase 1B, randomized, double-blinded, dose escalation, single-center, repeat dose safety and pharmacodynamics study of the oral NLRP3 inhibitor dapansutrile in subjects with NYHA II-III systolic heart failure

B 16, 602610

When we transition to patient-facing availability, it will be within a supervised medical program, not as a self-directed supplement

After five washing steps with PBS-Tween, the secondary antibody (Alexa Fluor 555 anti-mouse, Life Technologies, 1:200) was added in 2% BSA/PBS-Tween together with Hoechst 33342 (1 g/ml) for 2 h

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Transmission electron microscopy Cells were digested with 0.25% trypsin and 0.02% EDTA, washed with Hanks Balanced Salt Solution (HBSS)