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The PIONEER trials were among the first in T2D to utilize estimands based on regulatory guidelines during trial planning, trial conduct, data analysis, and interpretation of results [60]

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Decreases in sperm counts can be severe leading even to complete azoospermia

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The ideal candidate is generally an adult with a body mass index (BMI) of 27 or higher, with at least one weight-related health issue, or a BMI of 30 or greater without any additional health conditions