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Clinical trials show approximately 15-22% weight reduction over 68 weeks with semaglutide in weight-management studies

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Oral semaglutide has dramatically different pharmacokinetics, with only about 1% bioavailability compared to 89% for injections

But because it must be taken daily on an empty stomach with minimal water, and because absorption varies significantly day to day, achieving consistent steady-state levels takes longer and is less predictable

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