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"Many times obesity treatment is framed as a limited duration intervention that once people get to a weight goal or percentage of weight reduction, that then treatment can be discontinued," Almandoz says

This matters while clinical approval remains uncertain

Consistent with reports in other cancer types showing that GPX2 overexpression promotes cisplatin resistance by suppressing ROS accumulation, our findings suggest that NAC-associated upregulation of GPX2 may enhance intracellular antioxidant defenses, thereby promoting survival of residual tumor cells and contributing to chemoresistance [21, 22]

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However, clinical research commonly tests doses ranging from 250 to 600 milligrams per day, with the most effective results often observed at 500600 milligrams daily taken consistently for at least one to two months

doi:10.2147/jep.s35396