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Tellus B 58 , 196205 (2006)
Forty male mice (C57BL/6, Five-week-old) were randomly assigned to two dietary groups that were fed for 12 weeks a control diet ( n = 10, keaoxieli, 1016706476803973120) or a high-fat diet( n = 30, hyscbio, Research Diets D12492)
GHK-Cu is most stable and effective at a neutral pH, around 6 to 7
No DMSO prep needed
Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes
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