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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
A tissue-level metabolic study should ideally report: longitudinal body-weight curves rather than only a final value
Providing anti-inflammatory effects Data showed that NNMT increases collagens and inflammatory molecules, which worsen inflammation
Simple and straightforward: Hydrate well in the following hours, but no fasting or special restrictions are required
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