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When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Weeks 4 to 8: Improvements either plateau or persist

Citation7,Citation8 In one example, patient chair time for Rituximab IV administration ranged from approximately 3 to 5 h, but was reduced to approximately 10 min to 2.5 h by SC administration, with high variability depending on the country of the administration

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