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Unlike semaglutide which only targets GLP-1 receptors, tirzepatides additional GIP receptor activity is thought to enhance insulin secretion, improve insulin sensitivity, and produce greater reductions in appetite and body weight

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As suggested by the US NIA-Alzheimers Association, biomarkers of AD (hyperphosphorylated tau and A) have the necessary specificity for a diagnosis of AD, whereas tracers of brain metabolic changes such as [ 18 F]FDG serve to assess disease progression and treatment effect ( n = 14) approached but did not reach the number obtained by power calculation ( n = 16), leading us to be cautious with conclusions of this variable