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There is another group of SNOs called high-molecular mass (HMM) SNOs which are produced by NO binding to sulfhydryl (-SH) groups present in specific cysteine residues of proteins

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The cellular consequence is increased eumelanin synthesis, documented in the B16-F10 (murine melanoma), MNT-1 (human melanoma), and primary human melanocyte cultures

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NOTE: When using this product around the eye area, use fingertips to carefully apply a thin layer (or 1-2 drops) underneath the eyes or on the outside areas of the eye