One 2023 study in Circulation even found that clearing senescent cells, including with FOXO4-DRI, worsened pulmonary hypertension in rodents
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Participants in studies reported fewer signs of aging, such as wrinkles
In rare cases, mild gastrointestinal symptoms such as nausea, bloating, or abdominal discomfort may occur
10.1038/nrg.2018.4 91 KatsyubaE.RomaniM.HoferD.AuwerxJ
The -SH groups on these residues act as strong nucleophiles, which can conjugate with a variety of molecules, including other glutathione molecules