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Current therapeutic strategies for T2DM management prioritize metformin as the first-line pharmacological intervention, primarily through its dual mechanisms of suppressing hepatic gluconeogenesis and enhancing peripheral glucose utilization in skeletal muscle tissue 3,4

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Key findings from our study: Tirzepatide 15 mg and CagriSema demonstrated the greatest overall weight reduction CagriSema showed the strongest performance at the 20% weight loss threshold Higher efficacy was generally accompanied by increased gastrointestinal adverse events Serious adverse events remained broadly comparable to placebo across regimens As obesity medicine rapidly evolves toward multi-pathway and combination therapies, comparative evidence like this becomes increasingly important for individualized treatment decisions and future guideline development

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Weight Maintenance and the Fear of Regaining Once you hit your goal weight, the fear of regaining it is real