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Future research should focus on precise patient stratification, optimizing dosage and treatment timing, and exploring their potential for combination with ART

This isnt theoretical we see it clinically

The largest pool of folates is in the liver which can accumulate 50% of the total body folate content 895,896

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The jump from 4mg to 8mg is the largest absolute increase in the protocol and typically produces the most intense gastrointestinal adjustment period