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Therapy frame and future considerations Per the 2020 American College of Rheumatology guidelines, allopurinol is recommended as the initial therapeutic approach for symptomatic hyperuricemia, aiming to achieve a target serum uric acid level below 6 mg/dl

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DJH and BRR receive financial support from the Australian Research Council Linkage Projects scheme (LP140100095)

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Control siRNA as well as siRNAs against GAPDH and paxillin were obtained as pools consisting of four siRNAs

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