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The primary outcomes evaluated at this interim analysis (week 72, 800 patients) included resolution of steatohepatitis and reduction in liver fibrosis
No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise
Regulatory status Ozempic (for type 2 diabetes) and Wegovy (for weight management) are FDA-approved
While its primary role is in blood sugar regulation and weight management, semaglutide can also affect muscles and joints
A systematic review on the efficacy of GLP-1 receptor agonists in mitigating psychotropic drug-related weight gain
Oxidative stress in autism spectrum disorder
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