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STEP UP: higher dose exploration The STEP UP trial investigated a higher dose of 7.2 mg weekly, three times the standard 2.4 mg dose

The prior art also describes a synthesis method using Fmoc solid phase sequential one by one coupling, wherein Mmt, Mtt, Dde, or ivDde protecting group is selected for temporary orthogonal protection when an amino acid is coupled to the side chain of the lysine, and then a certain method is selected for removing the protecting groups, allowing to couple on the side chain in sequence

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