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For example, HepG2 cells exposed to 20 mM APAP for 24 h showed only a minor (8%) reduction in GSH content, a minor increase in protein adducts, no mitochondrial dysfunction and only a 2-fold increase in lactate dehydrogenase (LDH) release [142]
For instance, patients with multiple metabolic issues may benefit from combination agents like tirzepatide, as studies suggest it can lead to greater weight loss and reduced risk of developing type 2 diabetes compared to semaglutide
& Dillin, A
,
Tavares, N
In the STEP trials, adults taking semaglutide experienced significant weight loss compared with placebo
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