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Collectively, these findings indicate that prebiotics could be beneficial for managing conditions such as ME/CFS characterized by dysbiosis, increased intestinal permeability, and chronic inflammation

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Coffee also contains palmitic acid and caffeine, and when absorbed rectally, this stimulates the natural production of glutathione, a powerful antioxidant essential for liver detoxification, by up to 700%

The treatment of mice with daidzein and genistein (low dose 20 mg/kg or high dose 150200 mg/kg) for two weeks reversed the polyinosinic:polycytidylic acid [poly(I:C)]-induced decrease in locomotor activity and brain/skin gene expression, as well as serum levels of pro-inflammatory mediators relevant to CFS (i.e., TNF-, IL-6, keratinocytes-derived chemokine (IL-8/(CXC motif) ligand (CXC)L8 murine homolog), chemokine (CC motif) ligand-2, -4, -5 (CCL2, CCL4, CCL5) and C-X-C motif chemokine ligand 10 (CXCL10))