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The benefits appeared consistent regardless of baseline age, sex, BMI, New York Heart Association functional class, or diuretic use

The habenula, which has a high concentration of GLP1 receptors 22 could also participate in semaglutides actions as it is involved in the negative reinforcement in obesity 23 and in alcohol and other substance use disorders 24

10.1080/08941930903214719 24 GrabarevicZ.TisljarM.ArtukovicB.BratulicM.DzajaP.SeiwerthS.et al (1997)

Compounded medication may still be available if they fill a speicific individual patient need or dose that is not commercially available

For example, a 2022 study found that people taking a weekly injection of tirzepatide (commonly sold under the brand name Zepbound) lost between 15% and 20% of their body weight over 72 weeks

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