16 In individuals with established cardiovascular diseases, GLP-1RAs have been shown to significantly lower the risk of major adverse cardiovascular events
Elevated cAMP activates protein kinase A (PKA), which phosphorylates multiple targets including ion channels, transcription factors (notably CREB), and components of the insulin secretory machinery
This approach could enable initial treatment with highly effective but expensive GLP-1 agonists, followed by maintenance with more affordable alternatives
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Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, et al