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Never adjust or discontinue either medication without medical guidance
Two to three sessions per week of appropriate strength training, even brief sessions, can be more useful than trying to solve lean-mass concerns with food alone
Jump to: How much weight do people lose on each | How retatrutide and Mounjaro work differently | Side effects compared | What happens if you stop taking the medication | Cost and access in the UK | Cardiovascular and long-term safety | Muscle mass and body composition | Switching considerations | Who should consider which | Frequently asked questions | Take home message | Second Natures Mounjaro programme | References Retatrutide has produced larger weight loss than Mounjaro in trials so far, with an average weight loss of up to 28.7% at 68 weeks in retatrutides TRIUMPH-4 trial, compared with up to 22.5% at 72 weeks in Mounjaros SURMOUNT-1 trial
There's no confirmed date yet for when they will be available for weight loss
Primary study: Wilding and colleagues, 2022, Diabetes, Obesity and Metabolism
Review your weight and protein trend together weekly , not daily
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