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GLP-1 specifically binds to the glucagon-like peptide-1 receptor (GLP-1R) in the body, directly stimulating the secretion of insulin by pancreatic -cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect

It was designed by Al-Obeidi, Castrucci, Hadley and Hruby and reported in the Journal of Medicinal Chemistry in 1989, using quenched molecular dynamics to select which conformation of the alpha-MSH 4-10 message sequence to constrain

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On the other hand, some data on chronic administration of long acting GLP1RAs have established that deceleration of gastric emptying does continue albeit less compared to short-acting GLP1RAs

Contains L-carnitine, choline, ginseng, bitter orange extracts, manganese, and vitamins (C, B6, and B12)

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