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In BV2 microglial cells, BV2-metformin-loaded PLGA treatment downregulated inducible nitric oxide synthase (iNOS) expression (proinflammatory M1 phenotype) and upregulated mannose receptor (CD206) expression (anti-inflammatory M2 phenotype), leading to a more than three-fold elevation in the CD206/iNOS fluorescence intensity ratio

Haag, 2003)

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Warnings and Cautions KLOW peptide demands careful handling because of its experimental status and absence of regulatory approval for human use

Not approved for human consumption, therapeutic application, or veterinary use

As a result, ROS overproduction or underproduction can compromise cellular and tissue function, ultimately contributing to the pathogenesis of cardiovascular diseases, neurodegenerative diseases, metabolic diseases, reproductive system diseases, digestive diseases, respiratory system diseases, cancers, inflammation and infectious diseases (Fig