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Strait forward process
In SURPASS-2 (N=1,879), tirzepatide was compared directly to injectable semaglutide 1.0 mg (not Rybelsus) in adults with type 2 diabetes on metformin
All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)
Gastrointestinal side effects like diarrhea can lead to dehydration
The difference comes down to two things: where the medication comes from, and whos watching your labs
They deprived the rats of alcohol for 9 days and then gave them semaglutide
