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Central appetite suppression: Amylin crosses blood-brain barrier Activates area postrema (brainstem) Also acts on nucleus accumbens Direct satiety signaling Reduces desire to eat Different brain pathways than GLP-1 3

Wang 2011)

Mild side effects may occur, such as a slight redness at the injection site, although these usually go away within a few hours after the injection

Research suggests DSIP may modulate stress hormone levels, including potential effects on cortisol and ACTH

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Small boundaries reduce stress hormones more effectively than vague stress less goals