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It is now understood that myristoylation recruits FSP1 to the plasma membrane, where it functions as an oxidoreductase that reduces ubiquinone to ubiquinol, generating a lipophilic radical-trapping antioxidant (RTA) that counteracts lethal lipid peroxidation
Matsuda H, Hirata N, Kawaguchi Y, et al
Its low molecular weight and permeability allow it to reach intracellular enzyme targets directly, which is the property that makes it useful in cell-based metabolic assays
As a pentapeptide, it is specifically designed to bind to the growth hormone secretagogue receptor (GHS-R1a) with extreme precision
Smiroldo, J
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