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Inhibits NF-B signaling via p65 lysine 310 deacetylation, blocking p300/ac-p65 Lys310 signaling nuclear translocation in obese mices macrophages [179]
Patella, F
10.1016/s0958-1669(00)00199-3 55 UribeP
Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP
Studies are also underway for a spectrum of other conditions, including Phase 3 trials investigating non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA), as well as mid-to-late stage trials exploring potential benefits in neurodegenerative disorders like Parkinsons disease
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