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the lack of effects of dulaglutide on endothelial inflammation by SIRT1 siRNA evidences the involvement of SIRT1 pathway in this process (Luo et al., 2019)
In 2022, the FDA approved tirzepatide for the treatment of T2DM
Neuropsychiatric Applications Emmerich, M., et al
However, Tirzepatides dual GIP and GLP-1 receptor agonism may confer cataract protection through GIPs anti-inflammatory properties 24
TRIUMPH-4 is a more targeted study enrolling 445 patients with both obesity and knee osteoarthritis
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