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The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process ( GLP-1 is one of the hormones responsible for the incretin effect, and exerts a wide variety of actions such as potentiation of glucose-stimulated insulin secretion, reduction of appetite, delay of gastric emptying and inhibit cell dysfunction (Yu et al., 2015

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Comprehensive lab panel Estradiol, progesterone, testosterone (total and free), FSH, LH, DHEA-S, cortisol, thyroid markers

Biosci Rep (2020) 40(4):BSR20193160