Description Glutathione is a powerful antioxidant and detoxifying compound consisting of three amino acids: cysteine, glutamic acid, and glycine.* Produced in the liver, glutathione assists with detoxifying, maintains the integrity of blood cells, and helps transport amino acids across cell membranes
-Ketoglutarate may contribute to the restoration of ovarian reserve and improve pregnancy rates in a CTX-induced POI rat model, potentially by inhibiting Caspase-3 activity (Li T
Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance
J Autism Dev Disord 2009;39:544-6
Other contraindications and caution flags include Wilsons disease or another copper-handling disorder, pregnancy, recent surgery, and WADA-tested competition
doi: 10.1146/annurev-pharmtox-011112-140320 207
