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Gasoyan added that, in this large observational study of patients who discontinued semaglutide or tirzepatide, reinitiation of the original medication or receipt of alternative obesity treatment was common, which may explain why they regained less weight than patients in randomized trials. Additionally, previous research suggests that GLP-1 drug discontinuation often occurs for practical reasons rather than lack of effectiveness
About one out of every 100 cells lining our entire digestive tract acts as a nutrient sensor, and can secrete hormones accordingly, including GLP-1, glucagon-like peptide-1
Energy metabolism in ischemic heart disease Ischemic heart disease, caused by reduced coronary blood flow, profoundly affects cardiac energy metabolism (Fig