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Fan X, Li A, Yan Z, Geng X, Lian L, Lv H, Gao D, Zhang J

According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

197, 198, 199 The effect of diazoxide on cancer growth was examined in DMBA- and N-methyl-N-nitrosurea (MNU)-induced mammary carcinomas of the rat

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