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Whether GLP-1 receptor agonists also exert direct effects on immune cells is an area of ongoing preclinical and early clinical research, but this has not been established as a confirmed mechanism in NICE-approved treatment pathways and should be regarded as preliminary

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Oxidative stress, inflammation, and apoptosis are critical in HF progression

The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism

Retatrutide is not yet available