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For context, in one study of 175 people with overweight or obesity, participants taking semaglutide: Lost an average of 15 pounds (about 6% of their body weight) within three months Lost an average of 27 pounds (about 11% of their body weight) after six months Recommended lifestyle changes during GLP-1 therapy GLP-1 medications can boost weight loss by increasing satiety and reducing food cravings

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Both medications can begin reducing appetite early in treatment

Eating smaller, more frequent meals during the first month helps your body adjust to the slowed gastric emptying

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The headache may be caused by other factors such as dehydration or a reaction to the needle used for injection