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Prominent features include epithelial barrier dysfunction, delayed or accelerated gastrointestinal transit due to abnormal function of smooth muscles, dysfunctional enteric nervous system and/or immunity, gut microbial dysbiosis, bile acid malabsorption, and alterations in the gut-brain axis (812)

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Research observations often focus on how cells respond to stress, injury signals, and structural disruption when this peptide is present

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PMID: 22015471

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