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The metabolic profile is very similar to that in column 3 except that now the intracellular SAH concentration does not decline but instead increases by 24% in line with the clinical data
A total of 129 metabolites were finally identified, including 82 flavonoids (mainly including liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glabridin, licorice chalcone A, licorice chalcone B, apiose liquiritin, formononetin, etc.), 20 terpenoids (paeoniflorin, albiflorin, benzoylpaeoniflorin, oxypaeoniflorin, glycyrrhizic acid, etc.), 10 phenolic metabolites, 7 coumarins, and 10 other metabolites
Moreover, the serum level of IL-6 in lipopolysaccharide(LPS)-stimulated mice was significantly elevated compared to normal controls, further supporting the accuracy and effectiveness of this delivery strategy
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