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S.JernerenF.NellemannB.ValsdottirD.et al
This makes the peptide an attractive target for research related to lung inflammation
2006 Dec;25(6):886-96
Key trial programs include STEP (semaglutide, published in The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
For instance, bone marrow MSC-derived exosomes (BMSC-Exos) downregulate METTL3 expression, disrupt the m6A-mediated stabilization of ACSL4 mRNA, and ultimately reduce intracellular Fe + , ROS, and lipid peroxidation
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