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When amputation is due to diabetic peripheral vascular disease or gangrene, the diabetes code (e.g., E11.52 ) must be sequenced first, with the acquired absence code as a secondary code

Endocan is an important biomarker of endothelial dysfunction and inflammatory response (54), suggesting that inflammation may link skin inflammation, vascular endothelial damage, and the occurrence and development of ED at the molecular level by upregulating Endocan expression

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